Spectinomycin sulfate tetrahydrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Spectinomycin sulfate hydrate is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms.

Spectinomycin sulfate hydrate is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin sulfate hydrate acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin sulfate hydrate is also a noncompetitive inhibitor of td intron RNA with an Ki value of 7.2 mM-.

Spectinomycin sulfate hydrate (20 mg/kg; i.m.; 20-100 mg/kg; 9 d) 对健康小鸡表现出安全性。Spectinomycin sulfate hydrate (10 mg/kg; i.v.; single dose) 的主要消除途径是肾脏排泄，约 55% 以原形排泄到尿液中。Animal Model:Arbor Acres plus broiler chicks (15-day-old) Dosage:20 mg/kg, 60 mg/kg, 100 mg/kg Administration:Intramuscular injection (chest muscles); 9 days Result:Showed biosecurity of 20 mg/kg by complete blood count, biochemical parameters, histopathological, clinical signs, body weight gain, and feed conversion ratio (FCR).

Spectinomycin sulfate hydrate 选择性抑制细胞和大肠杆菌提取物中的蛋白质合成Spectinomycin sulfate hydrate (50 μg/mL) 可快速且可逆地抑制大肠杆菌生长，并立即抑制氨基酸掺入。Spectinomycin sulfate hydrate (1 μg/mL or 3 μM) 可抑制由内源性信使 RNA 或 MS-2 噬菌体 RNA 指导的多肽合成，在大肠杆菌提取物中的最大抑制率为 70-80% 。Spectinomycin sulfate hydrate 通过抑制结合来阻止肽基 tRNA 从 A 位易位到 P 位延伸因子 G 到核糖体。Spectinomycin sulfate hydrate 与 16S rRNA 中的残基 G1064 和 01192 特异性相互作用，并可能使其失活。Spectinomycin sulfate hydrate 表现出剪接抑制作用，并且依赖于 pH 变化和 Mg2+ 浓度，表明与内含子 RNA 存在静电相互作用。

硫酸大观霉素(四水)

Others

Other Targets

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64058-48-6

502.49

C14H34N2O15S

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years